The hypothesis of localized chemiosmosis is unsatisfactory.

Asymmetric cell-cell adhesion can trigger mitochondriogenesis: A hypothesis

Title 1 Asymmetric cell-cell adhesion can trigger mitochondriogenesis: A hypothesis 2 3 Author 4 Yasuhiro Naito* 5 6 Abstract 7 Without exception, modern hypotheses explaining the origin of eukaryotes assume evolution from 8 two (or more) distinct prokaryotes. Almost all prokaryotic cell membranes possess a chemiosmosis 9 system, whereas eukaryotic cell membranes have lost that ability. Neverth...

How did LUCA make a living? Chemiosmosis in the origin of life.

Despite thermodynamic, bioenergetic and phylogenetic failings, the 81-year-old concept of primordial soup remains central to mainstream thinking on the origin of life. But soup is homogeneous in pH and redox potential, and so has no capacity for energy coupling by chemiosmosis. Thermodynamic constraints make chemiosmosis strictly necessary for carbon and energy metabolism in all free-living che...

ON THE DISSIPATION OF THERMAL AND CHEMICAL ENERGIES ON THE EARLY EARTH The onsets of hydrothermal convection, chemiosmosis, genetically regulated metabolism and oxygenic photosynthesis

Manoj KM (Mar 2017) Debunking EPCR in mOxPhos; ARXIV

The prevailing half-a-century old explanation for cellular respiration solicits a synchronization of electron transfer chain (ETC) and proton pumping activity across the inner mitochondrial membrane, for generating a trans-membrane proton-electro-chemical potential. This outcome is supposedly harnessed by Complex V to synthesize ATP, working via a rotary mode. In the first part of my work (the ...

Manoj KM (Mar 2017) Murburn concept for mOxPhos; ARXIV

Via a concurrently communicated manuscript [Manoj, 2017], I have conclusively debunked the long-standing “Electron Transport Chain – Proton Pump – Chemiosmosis – Rotary ATP Synthesis” (EPCR) explanatory paradigm for mitochondrial oxidative phosphporylation (mOxPhos). Now, the mandate is open to establish a viable explanation for mOxPhos. Several similarities/parallels could be noted between mic...